Cancer Of The Head And Neck Myers Pdf Free
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INTRODUCTION The presence of nodal metastases remains the most significant predictive factor for regional recurrence and survival in patients treated for squamous cell carcinoma of the head and neck. Survival rates are further decreased in patients with nodal metastases that have spread beyond the lymph node capsule, or extracapsular spread (ECS). To the authors' knowledge, this is the first report on the impact of ECS in a large series of patients treated for squamous cell carcinoma of the oral tongue (SCCOT) at a single institution using surgery as the primary treatment modality. RESULTS Two hundred sixty‐six patients were included in the study. Of that number, 146 patients (55%) were pathologically node‐negative (pN0), 75 patients (28%) were pathologically node‐positive (pN+) without ECS (pN+/ECS−), and 45 patients (17%) were pN+ with ECS (pN+/ECS+). Kbco studio c volume 14 cds download. The 5‐year disease‐specific and overall survival rates for pN0 patients were 88% and 75%; for pN+/ECS− patients, 65% and 50%; and 48% and 30% for pN+/ECS+ patients. The patterns of failure for the pN0, pN+/ECS− and, pN+/ECS+ groups showed overall recurrence rates of 19.8%, 34.2%, and 51.1% with regional failure rates of 11.5%, 19.2%, and 28.9%, respectively, and distant metastases rates of 3.3%, 8.2%, and 24.4%.
Cancer Of The Head And Neck Myers Pdf Free
Squamous cell carcinoma of the oral tongue (SCCOT) is among the most common tumors of the upper aerodigestive tract, accounting for 6,900 new carcinoma cases and 1,700 carcinoma deaths in the United States each year. The standard treatment for SCCOT in the U.S. Patients identified as high risk for treatment failure on the basis of clinicopathologic criteria are also given adjuvant radiation therapy. Despite improvements in surgical and radiation therapy techniques, treatment is unsuccessful in many high‐risk patients, and the 5‐year survival rate for high‐risk patients has not improved significantly over the past 30 years, remaining at 30‐50%. The major modes of treatment failure are local recurrence in the tongue, regional recurrence in the cervical lymph nodes, and distant metastases. Regional recurrence is the predominant mode of failure. Previous studies of patients treated for squamous cell carcinoma of the head and neck (SCCHN) have shown that nodal metastases demonstrable on pathologic review (pN+ disease) is the most significant predictive factor for regional recurrence and death from disease.
Cancer Of The Head And Neck Myers Pdf Free Download
- Extranodal extension of tumor outside the lymph node capsule, or extracapsular spread (ECS), is another highly significant predictor of adverse treatment outcomes. -, - To determine the value of pN+/ECS+ in predicting the outcomes of patients with SCCOT treated with surgery as the primary modality, we retrospectively reviewed the medical records of all patients treated at a single institution over a 15‐year period. The goal of this study was to identify patterns of treatment failure in patients with pN+ disease and ECS to determine which patients would benefit most from intensification of adjuvant therapy and to facilitate the cellular and molecular analysis of the mechanisms of regional metastasis and ECS. Crack theatre of war 2.
METHODS A retrospective review of medical records of all patients treated at The University of Texas M. Anderson Cancer Center for SCCOT with resection of the primary tumor and neck dissection from January 1980 through December 1995 was performed. All patients with synchronous or metachronous lesions were excluded. We identified 266 patients who had undergone surgery that included a neck dissection.